Canine Cancer Precision Medicine: Genomic Landscapes and Actionability Horizons
Course Information
Date: AnytimeDuration: 90 Minutes
Location: Virtual
Audience: ACVIM, ECEIM, ECVIM-CA and ECVN Diplomates and candidates
Specialty: Oncology
Type: On Demand
CE Hours: 1.5
Course Information
Cancer is a genetic disease. The genomics revolution of the past two decades has provided detailed maps of the underpinnings of many human cancers through the generation of hundreds of thousands of cancer genome sequences. These data are increasingly leveraged to guide development of new clinical diagnostics, prognostics, and targeted treatments that are improving outcomes for human cancer patients. The genomics revolution has now also crossed into veterinary oncology, particularly in pet dogs, where nearly two thousand cancer genomes have been sequenced and published in the past five years alone. Although the path from mapping cancer genome landscapes to clinical translation is still under development, the oncoming flood of genomic data stands poised to transform veterinary oncology. We and others are charting the genomic landscapes of naturally occurring canine cancers in order to develop new clinical tools for veterinary oncology and to establish comparative settings in which clinical hypotheses can be rapidly tested across species. Here we will review cancer's genetic basis across species, summarize the history of and recent developments in naturally occurring canine cancer genomics, and discuss implications of these emerging data for development of new clinical tools in veterinary oncology including opportunities and challenges in leveraging these data.RACE Application Status
This module has been submitted and approved for 1.5 hours of continuing education credit in jurisdictions which recognize AAVSB RACE approval.
For additional questions, please contact us at Learning@ACVIM.org.
Presenter
William Hendricks, PhD
Assistant Professor, Integrated Cancer Genomics
Translational Genomics Research Institute (TGen)
Phoenix, Arizona
Dr. William Hendricks is an Assistant Professor of Integrated Cancer Genomics and Director of Institutional Research Initiatives at the Translational Genomics Research Institute (TGen) in Phoenix, Arizona. Dr. Hendricks completed doctoral and postdoctoral training at Johns Hopkins School of Medicine in the laboratories of Drs. Kenneth Kinzler, Bert Vogelstein, and Nickolas Papadopoulos before joining TGen in 2013 to develop programs in canine and human cancer precision medicine alongside Dr. Jeffrey Trent. His laboratory focuses on mapping genomic landscapes of canine and human cancers to drive development of new treatments and diagnostics across species.